Neurotrophic delivery in Alzheimer’s-model mice

Neurotrophic delivery in Alzheimer’s-model mice

Background/introduction Alzheimer’s disease (AD), which has emerged as one of the most common brain disorders, begins in the hippocampal formation and gradually spreads to the remaining brain at its most advanced stages, and is characterized partly by deposition of amyloid plaques in the brain tissue but also in the blood vessels themselves. Our studies have dealt with both the delivery of neur...

Effects of hyperoxia in alzheimers transgenic mice

Assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model

Objective(s): Exposing to stress may be associated with increased production of reactive oxygen species (ROS). Therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. It has been presented that brain-derived neurotrophic factor (BDNF) supports neurons against various neurodegenerative conditio...

Involvement of Mice Hippocampus Brain-derived Neurotrophic Factor in Diazinon-induced Depressive Behavior in Mice

Background: Diazinon (Dzn), an Organophosphorus (OP) pesticide, is extensively used in agriculture. Acetylcholinesterase inhibition is linked to OP toxicity, and there are major mental health concerns associated with the use of pesticides. The objective of this study was to assess the depressive behavior in an animal model following their exposure to Dzn and the effect on the Brain-Derived Neur...

assessment of oxidative stress parameters of brain-derived neurotrophic factor heterozygous mice in acute stress model

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...